The Maguire Laboratory
Ramirez SH, Hale JF, McCarthy S, Cardenas CL, Udeni Galpayage Dona KN, Hanlon KS, Hudry E, De La Cruz D, Ng C, Das S, Nguyen DM, Nammour J, Bennett RE, Andrews AA, Musolino PL, Maguire CA. An engineered AAV capsid mediates efficient transduction of pericytes and smooth muscle cells of the brain vasculature. Human Gene Therapy. 2023. https://doi.org/10.1089/hum.2022.211
Cheng M, Dietz L, Gong Y, Eichler F, Nammour J, Ng C, Grimm D, Maguire CA. Neutralizing antibody evasion and transduction with purified extracellular vesicle-enveloped AAV vectors. Accepted to Human Gene Therapy, August 8, 2021.
Gyorgy B, Maguire CA. Extracellular vesicles: Nature's nanoparticles for improving gene transfer with adeno-associated virus vectors. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 May;10(3):e1488. doi: 10.1002/wnan.1488. Epub 2017 Aug 11. Review.
Gyorgy B, Sage C, Indzhykulian AA, Scheffer DI, Brisson AR, Tan S, Wu X, Volak A, Mu D, Tamvakologos PI, Li Y, Fitzpatrick Z, Ericsson M, Breakefield XO, Corey DP*, Maguire CA*. Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV. Molecular Therapy. (2017). 2017 Feb 1;25(2):379-391 *Co-corresponding authors. Cover Image
Dashkoff J, Lerner EP, Truong N, Klickstein JA, Fan Z, Mu D, Maguire CA, Hyman BT, Hudry E. Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9. Molecular Therapy-Methods and Clinical Development, (2016) Dec 7;3:16081.
Merkel SF, Andrews AM, Lutton EM, Mu D, Hudry E, Hyman BT, Maguire CA*, Ramirez SH*. Trafficking of AAV vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells. Journal of Neurochemistry.(2016). Oct. 8. doi: 10.1111/jnc.13861.Epub ahead of print. *Co-corresponding authors.
Zappulli V, Friis KP, Fitzpatrick Z, Maguire CA, Breakefield XO. Extracellular vesicles and intercellular communication within the nervous system. J Clin Invest. 2016 Apr 1; 126(4):1198-207. PMID: 27035811.
Hudry E, Martin C, Gandhi S, Gyorgy B, Scheffer DI, Mu D, Merkel SF, Mingozzi F, Fitzpatrick Z, Dimant H, Masek M, Ragan T, Tan S, Brisson AR, Ramirez SH, Hyman BT, Maguire CA. Exosome-associated AAV as a robust and convenient neuroscience tool. Gene Therapy. 2016 Feb 2. Epub ahead of print.
Fitzpatrick F, Gyorgy B, Skog J, Maguire CA. Extracellular vesicles as enhancers of virus vector-mediated gene delivery. Human Gene Therapy. 2014. Sep;25(9):785-6. (Featured on Journal Cover).
Gyorgy B, Fitzpatrick F, Crommentuijn MH, Mu D, Maguire CA. Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo. Biomaterials. 2014. DOI: 10.1016/j.biomaterials.2014.05.032 *In vivo use of vexosomes to evade anti-AAV antibodies.
Atai NA, Balaj L, van Veen H, Breakefield XO, Jarzyna PA, Van Noorden CJ, Skog J, Maguire CA. Heparin blocks transfer of extracellular vesicles between donor and recipient cells. J Neurooncol. 2013 Dec;115(3):343-51.
Maguire CA, Crommentuijn MH, Mu D, Hudry E, Serrano-Pozo A, Hyman BT, Tannous BA. Mouse gender influences brain transduction by intravascularly administered AAV9. Mol Ther. 2013 Aug;21(8):1470-1.
Maguire CA, Bovenberg MS, Crommentuijn MH, Niers JM, Kerami M, Teng J, Sena-Esteves M, Badr CE, Tannous BA. Triple bioluminescence imaging for in vivo monitoring of cellular processes. Mol Ther Nucleic Acids. 2013 Jun 18
Maguire CA, Balaj L, Sivaraman S, Crommentuijn MH, Ericsson M, Mincheva-Nilsson L, Baranov V, Gianni D, Tannous BA, Sena-Esteves M, Breakefield XO, Skog J. Microvesicle-associated AAV vector as a novel gene delivery system. Mol Ther. 2012 May;20(5):960-71.*First paper on vexosomes.
Maguire CA, Gianni D, Meijer DH, Shaket LA, Wakimoto H, Rabkin SD, Gao G, Sena-Esteves M. Directed evolution of adeno-associated virus for glioma cell transduction. J Neurooncol. 2010 Feb;96(3):337-47.
Maguire CA, Meijer DH, LeRoy SG, Tierney LA, Broekman ML, Costa FF, Breakefield XO, Stemmer-Rachamimov A, Sena-Esteves M. Preventing growth of brain tumors by creating a zone of resistance. Mol Ther. 2008 Oct;16(10):1695-702