The main focus of the Maguire lab is the development of more potent and safer  gene delivery systemS to answer therapeutic challenges of today and tomorrow. One such technology is called exo-AAV. exo-AAV are enveloped adeno-associated virus (AAV) vectors. The envelope is derived from exosomes which are  lipid based nanoparticles released by cells. Exosomes have several properties which may enhance AAV-mediated gene delivery.
 From WIREs Nanomed Nanobiotechnol 2017, e1488. doi  10.1002/wnan.1488

From WIREs Nanomed Nanobiotechnol 2017, e1488. doi  10.1002/wnan.1488

  Example of a exo-AAV. Note double layer membrane of exosome and at least 5 AAV capsids inside. Cryo-EM performed by Professor Alain Brisson and Sisareuth Tan.

Example of a exo-AAV. Note double layer membrane of exosome and at least 5 AAV capsids inside. Cryo-EM performed by Professor Alain Brisson and Sisareuth Tan.