One of The main focuses of the Maguire lab is the development of a unique hybrid gene delivery system called exo-AAV. exo-AAV are enveloped adeno-associated virus (AAV) vectors. The envelope is derived from exosomes which are  lipid based nanoparticles released by cells. Exosomes have several properties which may enhance AAV-mediated gene delivery.

From WIREs Nanomed Nanobiotechnol 2017, e1488. doi  10.1002/wnan.1488

From WIREs Nanomed Nanobiotechnol 2017, e1488. doi  10.1002/wnan.1488

Example of a exo-AAV. Note double layer membrane of exosome and at least 5 AAV capsids inside. Cryo-EM performed by Professor Alain Brisson and Sisareuth Tan.

Example of a exo-AAV. Note double layer membrane of exosome and at least 5 AAV capsids inside. Cryo-EM performed by Professor Alain Brisson and Sisareuth Tan.