The main focus of the Maguire lab is the development of a unique hybrid gene delivery system called vexosomes. Vexosomes are endogenously enveloped adeno-associated virus (AAV) vectors. The envelope is derived from extracellular vesicles (EVs) which are endogenous lipid based nanoparticles released by cells. EVs have several properties which may enhance AAV-mediated gene delivery.

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Example of a vexosome. Note double layer membrane of exosome and at least 5 AAV capsids inside. Cryo-EM performed by Professor Alain Brisson and Sisareuth Tan.

Example of a vexosome. Note double layer membrane of exosome and at least 5 AAV capsids inside. Cryo-EM performed by Professor Alain Brisson and Sisareuth Tan.